Silvia Monticelli, PhD
Immunologia Molecolare
Direttore di laboratorio
Via Vela, 6
6500 Bellinzona,
Switzerland
- silvia.monticelli@irb.usi.ch
- +41 91 820 0354
- +41 91 820 0305
| Bio |
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Silvia Monticelli ha ottenuto il suo Dottorato in Biologia presso l’Università di Milano, dove si è specializzata in Biologia Molecolare. Dal luglio 2000 al gennaio 2007 è stata impegnata nel tirocinio di post-dottorato nel laboratorio di Anjana Rao presso il Center for Blood Research della Harvard Medical School di Boston (USA) e nel febbraio 2007 è entrata a far parte dell’Istituto di Ricerca in Biomedicina. La Dr.ssa Monticelli ha pubblicato diversi articoli relativi a vari aspetti dei meccanismi molecolari che stanno alla base dello sviluppo di patologie quali asma e allergie. Di recente si è dedicata sia allo studio del ruolo dei microRNA (una classe relativamente nuova di molecole regolatorie) nel controllo dello sviluppo e delle funzioni delle cellule del sistema immunitario. |
| Pubblicazioni |
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The role of miRNAs in mast cells and other innate immune cells S. Montagner, E. M. Orlandi, S. Merante, S. Monticelli in Immunol Rev (2013) vol. 253 pp12-24 |
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miR-146a and NF-kappaB1 Regulate Mast Cell Survival and T Lymphocyte Differentiation N. Rusca, L. Deho, S. Montagner, C. E. Zielinski, A. Sica, F. Sallusto, S. Monticelli in Mol Cell Biol (2012) vol. 32 pp4432-44 * Selected as "Article of significant interest" by the Editors |
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Negative regulators take center stage S. Monticelli, F. Sallusto in Nat Immunol (2012) vol. 13 pp719-20 |
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Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto in Nature (2012) vol. 484 pp514-8 |
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MiR-146a in Immunity and Disease N. Rusca, S. Monticelli in Mol Biol Int (2011) vol. 2011 pp437301 |
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MiR-221 Influences Effector Functions and Actin Cytoskeleton in Mast Cells R. J. Mayoral, L. Deho, N. Rusca, N. Bartonicek, H. K. Saini, A. J. Enright, S. Monticelli in PLoS One (2011) vol. 6 ppe26133 |
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Stable Overexpression of miRNAs in Bone Marrow-Derived Murine Mast Cells Using Lentiviral Expression Vectors R. J. Mayoral, S. Monticelli in Methods Mol Biol (2010) vol. 667 pp205-14 |
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Human mast cells and mastocytosis: harnessing microRNA expression as a new approach to therapy? L. Deho, S. Monticelli in Arch Immunol Ther Exp (Warsz) (2010) vol. 58 pp279-86 |
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MicroRNAs and the Immune System S. Monticelli in Methods in Molecular Biology (2010) vol. 667 pp330p. |
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MicroRNA-221-222 regulate the cell cycle in mast cells R. J. Mayoral, M. E. Pipkin, M. Pachkov, E. van Nimwegen, A. Rao, S. Monticelli in J Immunol (2009) vol. 182 pp433-45 |
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Genomics and the immune system M. E. Pipkin, S. Monticelli in Immunology (2008) vol. 124 pp23-32 |
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A role for microRNAs in the development of the immune system and in the pathogenesis of cancer C. Kanellopoulou, S. Monticelli in Semin Cancer Biol (2008) vol. 18 pp79-88 |
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Immunological applications of genomics S. Monticelli, S. Sharma, A. Rao in Genome Biol (2006) vol. 7 pp321 |
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Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes S. Monticelli, K. M. Ansel, D. U. Lee, A. Rao in Novartis Found Symp (2005) vol. 271 pp179-87; discussion 187-90, 198-9 |
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Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells S. Monticelli, D. U. Lee, J. Nardone, D. L. Bolton, A. Rao in Int Immunol (2005) vol. 17 pp1513-24 |
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MicroRNA profiling of the murine hematopoietic system S. Monticelli, K. M. Ansel, C. Xiao, N. D. Socci, A. M. Krichevsky, T. H. Thai, N. Rajewsky, D. S. Marks, C. Sander, K. Rajewsky, A. Rao, K. S. Kosik in Genome Biol (2005) vol. 6 ppR71 |
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Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity K. M. Ansel, R. J. Greenwald, S. Agarwal, C. H. Bassing, S. Monticelli, J. Interlandi, I. M. Djuretic, D. U. Lee, A. H. Sharpe, F. W. Alt, A. Rao in Nat Immunol (2004) vol. 5 pp1251-9 |
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Chromatin-level regulation of the IL10 gene in T cells S. H. Im, A. Hueber, S. Monticelli, K. H. Kang, A. Rao in J Biol Chem (2004) vol. 279 pp46818-25 |
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Role of NFAT proteins in IL13 gene transcription in mast cells S. Monticelli, D. C. Solymar, A. Rao in J Biol Chem (2004) vol. 279 pp36210-8 |
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NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription S. Monticelli, A. Rao in Eur J Immunol (2002) vol. 32 pp2971-8 |
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Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activation S. Monticelli, R. Ghittoni, M. Kabesch, D. Vercelli in Mol Immunol (2002) vol. 38 pp1129-38 |
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Molecular regulation of class switch recombination to IgE through epsilon germline transcription S. Monticelli, D. Vercelli in Allergy (2001) vol. 56 pp270-8 |
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Molecular regulation of IgE switching: let's walk hand in hand S. Monticelli, L. De Monte, D. Vercelli in Allergy (1998) vol. 53 pp6-8 |
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To E or not to E? Can an IL-4-induced B cell choose between IgE and IgG4? D. Vercelli, L. De Monte, S. Monticelli, C. Di Bartolo, A. Agresti in Int Arch Allergy Immunol (1998) vol. 116 pp1-4 |
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The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter C. P. Thienes, L. De Monte, S. Monticelli, M. Busslinger, H. J. Gould, D. Vercelli in J Immunol (1997) vol. 158 pp5874-82 |
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Regulation of human epsilon germline transcription: role of B-cell-specific activator protein L. De Monte, C. P. Thienes, S. Monticelli, M. Busslinger, H. J. Gould, D. Vercelli in Int Arch Allergy Immunol (1997) vol. 113 pp35-8 |
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The company they keep: How BSAP and other transcription factors may regulate the human ε germline promoter L. De Monte, S. Monticelli, bd1 A.K. Oehling, J.G. Huerta Lopez, Editors in Progress in Allergy and Clinical Immunology (1997) vol. 4 pp49-52 |