Marcus Thelen, PhD
Trasduzione del segnale
Direttore di laboratorio
Via Vela, 6
6500 Bellinzona,
Switzerland
- marcus.thelen@irb.usi.ch
- +41 91 820 0317
- +41 91 820 0305
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Marcus Thelen ha studiato biochimica all’Università di Tübingen (DE), ed ha ricevuto il PhD all’Università di Berna. In seguito si è trasferito al Theodor Kocher Institut del Università di Berna dove ha iniziato ad interessarsi di infiammazione e chemochine. Nel 1989 si è unito al gruppo di ricerca di fisiologia cellulare ed immunologia diretto da Alan Aderem presso il dipartimento di Cohn/Steinman alla Rockefeller University di New York. Materia di studio sono stati gli aspetti biochimici della fagocitosi mediati da citochine e endotossine e la trasduzione del segnale legata al riarrangiamento del citoscheletro. Nel 1992 ha ricevuto dal Fondo Nazionale Svizzero per la Ricerca il grant START per supporto alla carriera ed è tornato al Theodor Kocher Institut, dove ha creato un gruppo di ricerca volto allo studio dei meccanismi molecolari della trasduzione del segnale nei leucociti, con particolare attenzione alle via di attivazione dipendenti da chinasi e mediate da recettori per le chemochine. Nel 1994 ha ottenuto la venia docendi dall’Università di Berna ed in seguito nel 2001 è stato eletto professore onorario presso la stessa Università. Nel 2000 si è trasferito a Bellinzona dove ha contribuito alla creazione dell’IRB. Da allora, Marcus Thelen dirige il laboratorio di Trasduzione del Segnale. |
| Pubblicazioni |
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Immune response: steroids drive dendritic cells D. Jarrossay, M. Thelen in Nat Immunol (2013) vol. 14 pp424-426 |
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Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus V. Biajoux, A. Bignon, C. Freitas, V. Martinez, M. Thelen, G. Lima, J. Jakez-Ocampo, D. Emilie, L. Llorente, K. Balabanian in J Transl Med (2012) vol. 10 pp251 |
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Complementary methods provide evidence for the expression of CXCR7 on human B cells M. L. Humpert, M. Tzouros, S. Thelen, A. Bignon, A. Levoye, F. Arenzana-Seisdedos, K. Balabanian, F. Bachelerie, H. Langen, M. Thelen in Proteomics (2012) vol. 12 pp1938-48 |
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CCR2 Acts as Scavenger for CCL2 during Monocyte Chemotaxis S. Volpe, E. Cameroni, B. Moepps, S. Thelen, T. Apuzzo, M. Thelen in PLoS One (2012) vol. 7 ppe37208 |
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HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 M. Schiraldi, A. Raucci, L. M. Munoz, E. Livoti, B. Celona, E. Venereau, T. Apuzzo, F. De Marchis, M. Pedotti, A. Bachi, M. Thelen, L. Varani, M. Mellado, A. Proudfoot, M. E. Bianchi, M. Uguccioni in J Exp Med (2012) vol. 209 pp551-63 * Highlights, Nat. Rev. Immunol. 2012, 12:232 |
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Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses A. Viejo-Borbolla, N. Martinez-Martin, H. J. Nel, P. Rueda, R. Martin, S. Blanco, F. Arenzana-Seisdedos, M. Thelen, P. G. Fallon, A. Alcami in PLoS Pathog (2012) vol. 8 ppe1002497 |
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The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1alpha M. A. Barber, A. Hendrickx, M. Beullens, H. Ceulemans, D. Oxley, S. Thelen, M. Thelen, M. Bollen, H. C. Welch in Biochem J (2012) vol. 443 pp173-83 |
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Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor B. Boldajipour, M. Doitsidou, K. Tarbashevich, C. Laguri, S. R. Yu, J. Ries, K. Dumstrei, S. Thelen, J. Dorries, E. M. Messerschmidt, M. Thelen, P. Schwille, M. Brand, H. Lortat-Jacob, E. Raz in Development (2011) vol. 138 pp2909-14 |
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Polarization of migrating monocytic cells is independent of PI 3-kinase activity S. Volpe, S. Thelen, T. Pertel, M. J. Lohse, M. Thelen in PLoS One (2010) vol. 5 ppe10159 |
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CXCR7 functions as a scavenger for CXCL12 and CXCL11 U. Naumann, E. Cameroni, M. Pruenster, H. Mahabaleshwar, E. Raz, H. G. Zerwes, A. Rot, M. Thelen in PLoS One (2010) vol. 5 ppe9175 |
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Chemokine receptor oligomerization: functional considerations M. Thelen, L. M. Munoz, J. M. Rodriguez-Frade, M. Mellado in Curr Opin Pharmacol (2010) vol. 10 pp38-43 |
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How chemokines invite leukocytes to dance M. Thelen, J. V. Stein in Nat Immunol (2008) vol. 9 pp953-9 |
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A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells T. N. Hartmann, V. Grabovsky, R. Pasvolsky, Z. Shulman, E. C. Buss, A. Spiegel, A. Nagler, T. Lapidot, M. Thelen, R. Alon in J Leukoc Biol (2008) vol. 84 pp1130-40 |
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CXCR7, CXCR4 and CXCL12: an eccentric trio? M. Thelen, S. Thelen in J Neuroimmunol (2008) vol. 198 pp9-13 |
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Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase M. A. Barber, S. Donald, S. Thelen, K. E. Anderson, M. Thelen, H. C. Welch in J Biol Chem (2007) vol. 282 pp29967-76 |
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Bcl10 controls TCR- and FcgammaR-induced actin polymerization D. Rueda, O. Gaide, L. Ho, E. Lewkowicz, F. Niedergang, S. Hailfinger, F. Rebeaud, M. Guzzardi, B. Conne, M. Thelen, J. Delon, U. Ferch, T. W. Mak, J. Ruland, J. Schwaller, M. Thome in J Immunol (2007) vol. 178 pp4373-84 |
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Differences in CXCR4-mediated signaling in B cells E. Palmesino, B. Moepps, P. Gierschik, M. Thelen in Immunobiology (2006) vol. 211 pp377-89 |
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Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells S. Infantino, B. Moepps, M. Thelen in J Immunol (2006) vol. 176 pp2197-207 |
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P-Rex1 regulates neutrophil function H. C. Welch, A. M. Condliffe, L. J. Milne, G. J. Ferguson, K. Hill, L. M. Webb, K. Okkenhaug, W. J. Coadwell, S. R. Andrews, M. Thelen, G. E. Jones, P. T. Hawkins, L. R. Stephens in Curr Biol (2005) vol. 15 pp1867-73 |
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The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes K. Balabanian, B. Lagane, S. Infantino, K. Y. Chow, J. Harriague, B. Moepps, F. Arenzana-Seisdedos, M. Thelen, F. Bachelerie in J Biol Chem (2005) vol. 280 pp35760-6 |
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Unusual chemokine receptor antagonism involving a mitogen-activated protein kinase pathway P. Ogilvie, S. Thelen, B. Moepps, P. Gierschik, A. C. da Silva Campos, M. Baggiolini, M. Thelen in J Immunol (2004) vol. 172 pp6715-22 |
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Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation S. A. Didichenko, C. M. Fragoso, M. Thelen in J Biol Chem (2003) vol. 278 pp26055-64 |
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Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles S. A. Didichenko, M. Thelen in J Biol Chem (2001) vol. 276 pp48135-42 |
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Is dimerization of chemokine receptors functionally relevant? M. Thelen, M. Baggiolini in Sci STKE (2001) vol. 2001 ppPE34 |
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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane S. M. Maira, I. Galetic, D. P. Brazil, S. Kaech, E. Ingley, M. Thelen, B. A. Hemmings in Science (2001) vol. 294 pp374-80 |
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Dancing to the tune of chemokines M. Thelen in Nat Immunol (2001) vol. 2 pp129-34 |
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Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes M. B. Delgado, I. Clark-Lewis, P. Loetscher, H. Langen, M. Thelen, M. Baggiolini, M. Wolf in Eur J Immunol (2001) vol. 31 pp699-707 |
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Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells N. Djouder, G. Schmidt, M. Frings, A. Cavalie, M. Thelen, K. Aktories in J Immunol (2001) vol. 166 pp1627-34 |
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Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase S. A. Didichenko, A. W. Segal, M. Thelen in FEBS Lett (2000) vol. 485 pp147-52 |
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Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes B. Tilton, L. Ho, E. Oberlin, P. Loetscher, F. Baleux, I. Clark-Lewis, M. Thelen in J Exp Med (2000) vol. 192 pp313-24 |
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GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism T. Laux, K. Fukami, M. Thelen, T. Golub, D. Frey, P. Caroni in J Cell Biol (2000) vol. 149 pp1455-72 |
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Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine A. Amara, O. Lorthioir, A. Valenzuela, A. Magerus, M. Thelen, M. Montes, J. L. Virelizier, M. Delepierre, F. Baleux, H. Lortat-Jacob, F. Arenzana-Seisdedos in J Biol Chem (1999) vol. 274 pp23916-25 |
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Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene C. M. Stover, S. Thiel, M. Thelen, N. J. Lynch, T. Vorup-Jensen, J. C. Jensenius, W. J. Schwaeble in J Immunol (1999) vol. 162 pp3481-90 |
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Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress R. Meier, M. Thelen, B. A. Hemmings in EMBO J (1998) vol. 17 pp7294-303 |
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Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils D. M. Sanghavi, M. Thelen, N. A. Thornberry, L. Casciola-Rosen, A. Rosen in FEBS Lett (1998) vol. 422 pp179-84 |
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G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils M. Thelen, S. A. Didichenko in Ann N Y Acad Sci (1997) vol. 832 pp368-82 |
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G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes B. Tilton, M. Andjelkovic, S. A. Didichenko, B. A. Hemmings, M. Thelen in J Biol Chem (1997) vol. 272 pp28096-101 |
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Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa I. Ibarrola, P. J. Vossebeld, C. H. Homburg, M. Thelen, D. Roos, A. J. Verhoeven in Biochim Biophys Acta (1997) vol. 1357 pp348-58 |
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Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes U. Forssmann, M. Uguccioni, P. Loetscher, C. A. Dahinden, H. Langen, M. Thelen, M. Baggiolini in J Exp Med (1997) vol. 185 pp2171-6 |
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Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils U. Wirthmueller, B. Dewald, M. Thelen, M. K. Schafer, C. Stover, K. Whaley, J. North, P. Eggleton, K. B. Reid, W. J. Schwaeble in J Immunol (1997) vol. 158 pp4444-51 |
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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 L. R. Stephens, A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A. S. Smrcka, M. Thelen, K. Cadwallader, P. Tempst, P. T. Hawkins in Cell (1997) vol. 89 pp105-14 |
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Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 D. Besser, A. Bardelli, S. Didichenko, M. Thelen, P. M. Comoglio, C. Ponzetto, Y. Nagamine in Oncogene (1997) vol. 14 pp705-11 |
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Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase S. A. Didichenko, B. Tilton, B. A. Hemmings, K. Ballmer-Hofer, M. Thelen in Curr Biol (1996) vol. 6 pp1271-8 |
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Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin M. Uguccioni, P. Loetscher, U. Forssmann, B. Dewald, H. Li, S. H. Lima, Y. Li, B. Kreider, G. Garotta, M. Thelen, M. Baggiolini in J Exp Med (1996) vol. 183 pp2379-84 |
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PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes M. Thelen, M. Uguccioni, J. Bosiger in Biochem Biophys Res Commun (1995) vol. 217 pp1255-62 |
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A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2) S. A. Jones, B. Moser, M. Thelen in FEBS Lett (1995) vol. 364 pp211-4 |
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Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes M. Thelen, M. P. Wymann, H. Langen in Proc Natl Acad Sci U S A (1994) vol. 91 pp4960-4 |
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Phospholipases and protein kinases during phagocyte activation M. Thelen, U. Wirthmueller in Curr Opin Immunol (1994) vol. 6 pp106-12 |
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Neutrophil signal transduction and activation of the respiratory burst M. Thelen, B. Dewald, M. Baggiolini in Physiol Rev (1993) vol. 73 pp797-821 |
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MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin J. H. Hartwig, M. Thelen, A. Rosen, P. A. Janmey, A. C. Nairn, A. Aderem in Nature (1992) vol. 356 pp618-22 |
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Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane M. Thelen, A. Rosen, A. C. Nairn, A. Aderem in Nature (1991) vol. 351 pp320-2 |
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GM-1, a clone of the monoblastic phagocyte U937 that expresses a large respiratory burst capacity upon activation with interferon-gamma G. Garotta, M. Thelen, D. Delia, M. Kamber, M. Baggiolini in J Leukoc Biol (1991) vol. 49 pp294-301 |
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The phagocytes and the respiratory burst M. Baggiolini, M. Thelen H. Sies, Editors in Oxidative Stress II (1991) pp399-420 |
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Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia A. Rosen, K. F. Keenan, M. Thelen, A. C. Nairn, A. Aderem in J Exp Med (1990) vol. 172 pp1211-5 |
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Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate M. Thelen, A. Rosen, A. C. Nairn, A. Aderem in Proc Natl Acad Sci U S A (1990) vol. 87 pp5603-7 |
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Reconstitution of cell-free NADPH-oxidase from human monocytes and comparison with neutrophils M. Thelen, M. Baggiolini in Blood (1990) vol. 75 pp2223-8 |
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Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils B. Dewald, M. Thelen, M. P. Wymann, M. Baggiolini in Biochem J (1989) vol. 264 pp879-84 |
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Structure and properties of a novel neutrophil-activating factor (NAF) produced by human monocytes A. Walz, P. Peveri, H. Aschauer, M. Thelen, P. Kernen, B. Dewald, M. Baggiolini in Agents Actions (1989) vol. 26 pp148-50 |
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[Properties and activation mechanism of neutrophilic leukocytes] M. Baggiolini, D. A. Deranleau, B. Dewald, M. Thelen, V. von Tscharner, M. P. Wymann in Arzneimittelforschung (1989) vol. 39 pp177-80 |
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Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor I. Lindley, H. Aschauer, J. M. Seifert, C. Lam, W. Brunowsky, E. Kownatzki, M. Thelen, P. Peveri, B. Dewald, V. von Tscharner, et al. in Proc Natl Acad Sci U S A (1988) vol. 85 pp9199-203 |
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Two transduction sequences are necessary for neutrophil activation by receptor agonists B. Dewald, M. Thelen, M. Baggiolini in J Biol Chem (1988) vol. 263 pp16179-84 |
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Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist M. Thelen, P. Peveri, P. Kernen, V. von Tscharner, A. Walz, M. Baggiolini in FASEB J (1988) vol. 2 pp2702-6 |
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Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation M. Thelen, M. Wolf, M. Baggiolini in J Clin Invest (1988) vol. 81 pp1889-95 |
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Effects of PAF on neutrophils and mononuclear phagocytes M. Baggiolini, B. Dewald, M. Thelen in Prog Biochem Pharmacol (1988) vol. 22 pp90-105 |
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The neutrophil leukocyte. Properties and mechanism of activation M. Baggiolini, D. A. Deranleau, B. Dewald, M. Thelen, von Tscharner. V. et al. N. Latruffe, Y. Gaudemer, P. Vignais, A. Azzi, Editors in Dynamics of Membrane Proteins and Cellular Energetics (1988) pp83-97 |
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Functional reconstitution of proton-pumping cytochrome-c oxidase in phospholipid vesicles M. Muller, M. Thelen, P. O'Shea, A. Azzi in Methods Enzymol (1986) vol. 126 pp78-87 |
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New insights on the cytochrome c oxidase proton pump M. Thelen, P. S. O'Shea, A. Azzi in Biochem J (1985) vol. 227 pp163-7 |
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Proton translocation by a native and subunit III-depleted cytochrome c oxidase reconstituted into phospholipid vesicles. Use of fluorescein-phosphatidylethanolamine as an intravesicular pH indicator M. Thelen, P. S. O'Shea, G. Petrone, A. Azzi in J Biol Chem (1985) vol. 260 pp3626-31 |
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Molecular properties of reconstituted cytochrome c oxidase: new evidence supports vectorial proton translocation A. Azzi, M. Muller, P. O'Shea, M. Thelen in J Inorg Biochem (1985) vol. 23 pp341-7 |
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Criteria for the measurement of proton translocation by reconstituted membrane proteins: cytochrome c oxidase P. O'Shea, M. Thelen, A. Azzi in Biochem. Soc. Trans. (1985) pp685-686 |
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Studies on the molecular basis of H+ transfer through phospholipid membranes P. O'Shea, M. Thelen, A. Azzi in Biochem. Soc. Trans. (1985) pp682-683 |
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On the logic of the application of double-inhibitor titrations for the elucidation of the mechanisms of energy coupling P. S. O'Shea, M. Thelen in FEBS Lett (1984) vol. 176 pp79-82 |
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The use of fluorescein-dipalmitoylphosphatidylethanolamine for measuring pH-changes in the internal compartment of phospholipid vesicles M. Thelen, G. Petrone, P. S. O'Shea, A. Azzi in Biochim Biophys Acta (1984) vol. 766 pp161-8 |
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Intra-vesicular pH-changes in cytochrome c oxidase vesicles as a result of ferrocytochrome c oxidation M. Thelen, P. O'Shea, G. Petrone, A. Azzi (1984) pp169-170 |
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Drug-induced lipid peroxidation in mice--V. Ethane production and glutathione release in the isolated liver upon perfusion with acetaminophen M. Thelen, A. Wendel in Biochem Pharmacol (1983) vol. 32 pp1701-6 |
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Studies on the molecular basis of H+ translocation by cytochrome c oxidase R. P. Casey, C. Broger, M. Thelen, A. Azzi in J Bioenerg Biomembr (1981) vol. 13 pp219-28 |
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Dicyclohexylcarbodiimide binds specifically and covalently to cytochrome c oxidase while inhibiting its H+-translocating activity R. P. Casey, M. Thelen, A. Azzi in J Biol Chem (1980) vol. 255 pp3994-4000 |
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The proton pump of cytochrome c oxidase: Inhibition by carbodiimides A. Azzi, R. P. Casey, M. Thelen (1980) pp21-22 |
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Dicyclohexylcarbodiimide inhibits proton translocation by cytochrome c oxidase R. P. Casey, M. Thelen, A. Azzi in Biochem Biophys Res Commun (1979) vol. 87 pp1044-51 |
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Hydrophobic interactions, proton movements and dicyclohexylcarbodiimide labeling of cytochrome c oxidase A. Azzi, R. Bisson, R. P. Casey, H. Gutweniger, C. Montecucco, M. Thelen, et al. C.P. Lee, G. Schatz, L. Ernster, Editors in Membrane Bioenergetics (1979) pp13-20 |
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The application of fluorescence spectroscopy to the study of biological membranes R. P. Casey, M. Thelen, A. Azzi A. Azzi, U. Brodbeck, P. Zahler, Editors in Membrane proteins (1979) pp194-208 |
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The modes of inhibition of proton translocation by cytochrome c oxidase R. P. Casey, M. Thelen, A. Azzi U. Weser, Editors in Metalloproteins: Structure, Model Function and Clinical Chemistry (1979) pp57-61 |