Fabio Grassi, MD, PhD
T Cell Development
Group Leader
Via Vela, 6
6500 Bellinzona,
Switzerland
- fabio.grassi@irb.usi.ch
- +41 91 820 0323
- +41 91 820 0305
| Bio |
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Fabio Grassi earned his degree in Medicine at the University of Pavia in 1985 and a Ph.D. in Microbiology at the University of Milan in 1993. He was a Anna Villa Rusconi fellow at the University of Umeä in Sweden (1988), post-doctoral fellow at the Institut Pasteur in Paris (1989-1993), assistant professor at San Raffaele Scientific Institute in Milan (1994-1998), Marie Curie fellow at Hôpital Necker in Paris (1998-2000) and Special Fellow of the Leukemia & Lymphoma Society at Dana Farber Cancer Institute, Harvard Medical School in Boston (2000-2002). He is associate professor of Biology at the Medical School of the University of Milan. In September 2002, he joined the IRB as head of the T Cell Development lab. His research is focused on various aspects of T cell physiology, including protein and membrane trafficking, signal transduction, control of cell growth and intercellular communications during T cell development and in immunopathological conditions. |
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Remote system for monitoring animal models with single-metabolite bio-nano-sensors S. Carrara, L. Bolomey, C. Boero, A. Cavallini, E. Meurville, G. De Micheli, T. Rezzonico Jost, M. Proietti, F. Grassi in IEEE Sensors Journal (2013) vol. 13 pp1018-1024 |
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Effect of the Purinergic Inhibitor Oxidized-ATP in a Model of Islet Allograft Rejection A. Vergani, C. Fotino, F. D'Addio, S. Tezza, M. Podetta, F. Gatti, M. Chin, R. Bassi, R. D. Molano, D. Corradi, R. Gatti, M. E. Ferrero, A. Secchi, F. Grassi, C. Ricordi, M. H. Sayegh, P. Maffi, A. Pileggi, P. Fiorina in Diabetes (2013) |
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Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7 A. Vergani, S. Tezza, F. D'Addio, C. Fotino, K. Liu, M. Niewczas, R. Bassi, R. D. Molano, S. Kleffel, A. Petrelli, A. Soleti, E. Ammirati, M. Frigerio, G. Visner, F. Grassi, M. E. Ferrero, D. Corradi, R. Abdi, C. Ricordi, M. H. Sayegh, A. Pileggi, P. Fiorina in Circulation (2013) vol. 127 pp463-75 |
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Phenotypic analysis and isolation of murine hematopoietic stem cells and lineage-committed progenitors M. Frascoli, M. Proietti, F. Grassi in J Vis Exp (2012) |
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Anti-CD3{varepsilon} mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications V. Marrella, P. L. Poliani, E. Fontana, A. Casati, V. Maina, B. Cassani, F. Ficara, M. Cominelli, F. Schena, M. Paulis, E. Traggiai, P. Vezzoni, F. Grassi, A. Villa in Blood (2012) vol. 120 pp1005-14 |
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Purinergic P2X7 Receptor Drives T Cell Lineage Choice and Shapes Peripheral gammadelta Cells M. Frascoli, J. Marcandalli, U. Schenk, F. Grassi in J Immunol (2012) vol. 189 pp174-80 |
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Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells M. T. Pallotta, C. Orabona, C. Volpi, C. Vacca, M. L. Belladonna, R. Bianchi, G. Servillo, C. Brunacci, M. Calvitti, S. Bicciato, E. M. Mazza, L. Boon, F. Grassi, M. C. Fioretti, F. Fallarino, P. Puccetti, U. Grohmann in Nat Immunol (2011) vol. 12 pp870-8 |
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Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen-induced arthritis V. Ardissone, E. Radaelli, P. Zaratin, M. Ardizzone, C. Ladel, M. Gattorno, A. Martini, F. Grassi, E. Traggiai in Arthritis Rheum (2011) vol. 63 pp3323-32 |
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ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors U. Schenk, M. Frascoli, M. Proietti, R. Geffers, E. Traggiai, J. Buer, C. Ricordi, A. M. Westendorf, F. Grassi in Sci Signal (2011) vol. 4 ppra12 |
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Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP A. Casati, M. Frascoli, E. Traggiai, M. Proietti, U. Schenk, F. Grassi in Cell Death Differ (2011) vol. 18 pp396-404 |
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Purinergic control of neutrophil activation F. Grassi in J Mol Cell Biol (2010) vol. 2 pp176-7 |
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Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation E. Traggiai, A. Casati, M. Frascoli, S. Porcellini, M. Ponzoni, F. Sanvito, L. Leng, R. Bucala, L. Moretta, F. Grassi in PLoS One (2010) vol. 5 ppe11262 |
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Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome B. Cassani, P. L. Poliani, V. Marrella, F. Schena, A. V. Sauer, M. Ravanini, D. Strina, C. E. Busse, S. Regenass, H. Wardemann, A. Martini, F. Facchetti, M. van der Burg, A. G. Rolink, P. Vezzoni, F. Grassi, E. Traggiai, A. Villa in J Exp Med (2010) vol. 207 pp1525-40 |
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Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF L. Dolcetti, E. Peranzoni, S. Ugel, I. Marigo, A. Fernandez Gomez, C. Mesa, M. Geilich, G. Winkels, E. Traggiai, A. Casati, F. Grassi, V. Bronte in Eur J Immunol (2010) vol. 40 pp22-35 |
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Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels U. Schenk, A. M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, F. Grassi in Sci Signal (2008) vol. 1 ppra6 |
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Recombinase-deficient T cell development by selective accumulation of CD3 into lipid rafts D. Ferrera, M. Panigada, S. Porcellini, F. Grassi in Eur J Immunol (2008) vol. 38 pp1148-56 |
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Of Omenn and mice V. Marrella, P. L. Poliani, C. Sobacchi, F. Grassi, A. Villa in Trends Immunol (2008) vol. 29 pp133-40 |
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A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome V. Marrella, P. L. Poliani, A. Casati, F. Rucci, L. Frascoli, M. L. Gougeon, B. Lemercier, M. Bosticardo, M. Ravanini, M. Battaglia, M. G. Roncarolo, M. Cavazzana-Calvo, F. Facchetti, L. D. Notarangelo, P. Vezzoni, F. Grassi, A. Villa in J Clin Invest (2007) vol. 117 pp1260-9 |
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Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling A. F. Campese, A. I. Garbe, F. Zhang, F. Grassi, I. Screpanti, H. von Boehmer in Blood (2006) vol. 108 pp305-10 |
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Regulation of peripheral T cell activation by calreticulin S. Porcellini, E. Traggiai, U. Schenk, D. Ferrera, M. Matteoli, A. Lanzavecchia, M. Michalak, F. Grassi in J Exp Med (2006) vol. 203 pp461-71 |
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Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors D. Penkov, P. Di Rosa, L. Fernandez Diaz, V. Basso, E. Ferretti, F. Grassi, A. Mondino, F. Blasi in Mol Cell Biol (2005) vol. 25 pp10768-81 |
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Improved thymopoietic potential in aviremic HIV infected individuals treated with HAART by intermittent IL-2 administration S. Porcellini, G. Vallanti, S. Nozza, G. Poli, A. Lazzarin, G. Tambussi, A. G. Siccardi, F. Grassi in AIDS (2003) vol. 17 pp1621-30 |
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Thymic selection revisited: how essential is it? H. von Boehmer, I. Aifantis, F. Gounari, O. Azogui, L. Haughn, I. Apostolou, E. Jaeckel, F. Grassi, L. Klein in Immunol Rev (2003) vol. 191 pp62-78 |
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Constitutive endocytosis and degradation of the pre-T cell receptor M. Panigada, S. Porcellini, E. Barbier, S. Hoeflinger, P. A. Cazenave, H. Gu, H. Band, H. von Boehmer, F. Grassi in J Exp Med (2002) vol. 195 pp1585-97 |
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On the brink of becoming a T cell C. Borowski, C. Martin, F. Gounari, L. Haughn, I. Aifantis, F. Grassi, H. von Boehmer in Curr Opin Immunol (2002) vol. 14 pp200-6 |
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Identification of a promiscuous T-cell epitope in Mycobacterium tuberculosis Mce proteins M. Panigada, T. Sturniolo, G. Besozzi, M. G. Boccieri, F. Sinigaglia, G. G. Grassi, F. Grassi in Infect Immun (2002) vol. 70 pp79-85 |
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A role for CD8 in limiting degeneracy of thymocyte selection E. Barbier, P. A. Cazenav, F. Grassi in Cell Mol Biol (Noisy-le-grand) (2001) vol. 47 pp129-33 |
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Different initiation of pre-TCR and gammadeltaTCR signalling C. Saint-Ruf, M. Panigada, O. Azogui, P. Debey, H. von Boehmer, F. Grassi in Nature (2000) vol. 406 pp524-7 |
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The impact of pre-T-cell receptor signals on gene expression in developing T cells H. von Boehmer, I. Aifantis, O. Azogui, C. Saint-Ruf, F. Grassi in Cold Spring Harb Symp Quant Biol (1999) vol. 64 pp283-9 |
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Molecular and cellular aspects of induced thymus development in recombinase-deficient mice S. Porcellini, M. Panigada, F. Grassi in Eur J Immunol (1999) vol. 29 pp2476-83 |
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The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice S. Calogero, F. Grassi, A. Aguzzi, T. Voigtlander, P. Ferrier, S. Ferrari, M. E. Bianchi in Nat Genet (1999) vol. 22 pp276-80 |
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GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk M. Panigada, S. Porcellini, F. Sutti, L. Doneda, O. Pozzoli, G. G. Consalez, M. Guttinger, F. Grassi in Mech Dev (1999) vol. 81 pp103-13 |
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Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes F. Grassi, E. Barbier, S. Porcellini, H. von Boehmer, P. A. Cazenave in J Immunol (1999) vol. 162 pp2589-96 |
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Expression pattern of the epithelial v-like antigen (Eva) transcript suggests a possible role in placental morphogenesis T. Teesalu, F. Grassi, M. Guttinger in Dev Genet (1998) vol. 23 pp317-23 |
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Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis M. Guttinger, F. Sutti, M. Panigada, S. Porcellini, B. Merati, M. Mariani, T. Teesalu, G. G. Consalez, F. Grassi in J Cell Biol (1998) vol. 141 pp1061-71 |
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Early degenerate selection of thymocytes by class I major histocompatibility complex F. Grassi, E. Barbier, P. A. Cazenave in Eur J Immunol (1994) vol. 24 pp627-34 |
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Intrathymic development of mouse alfa-beta and gamma-delta lympyhocytes F. Grassi, P. A. Cazenave, D. Rueff-Juy in Bullettin de l'Institut Pasteur (1994) vol. 92 pp197-211 |
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Human immunodeficiency virus type 1 gp120 C5 region mimics the HLA class I alpha 1 peptide-binding domain L. Lopalco, C. De Santis, R. Meneveri, R. Longhi, E. Ginelli, F. Grassi, A. G. Siccardi, A. Beretta in Eur J Immunol (1993) vol. 23 pp2016-21 |
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Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains F. Grassi, R. Meneveri, M. Gullberg, L. Lopalco, G. B. Rossi, P. Lanza, C. De Santis, G. Brattsand, S. Butto, E. Ginelli, et al. in J Exp Med (1991) vol. 174 pp53-62 |
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Chemical residues of ganglioside molecules involved in interactions with lymphocyte surface targets leading to CD4 masking and inhibition of mitogenic proliferation F. Grassi, L. Lopalco, P. Lanza, F. Ciccomascolo, F. Cazzola, A. Di Martino, G. Kirschner, L. Callegaro, L. Chieco-Bianchi, A. G. Siccardi in Eur J Immunol (1990) vol. 20 pp145-50 |
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Idiotypic replica of an anti-human tumor-associated antigen monoclonal antibody. Analysis of monoclonal Ab1 and Ab3 fine specificity G. Viale, G. Flamini, F. Grassi, R. Buffa, P. G. Natali, M. Pelagi, F. Leoni, S. Menard, A. G. Siccardi in J Immunol (1989) vol. 143 pp4338-44 |
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Anti-human tumor antibodies induced in mice and rabbits by "internal image" anti-idiotypic monoclonal immunoglobulins G. Viale, F. Grassi, M. Pelagi, R. Alzani, S. Menard, S. Miotti, R. Buffa, A. Gini, A. G. Siccardi in J Immunol (1987) vol. 139 pp4250-5 |
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HIV env glycoprotein shares a cross-reacting epitope with a surface protein present on activated human monocytes and involved in antigen presentation A. Beretta, F. Grassi, M. Pelagi, A. Clivio, C. Parravicini, G. Giovinazzo, F. Andronico, L. Lopalco, P. Verani, S. Butto, et al. in Eur J Immunol (1987) vol. 17 pp1793-8 |
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Effect of beta-lactam antibiotics on migration and bactericidal activity of human phagocytes A. Fietta, F. Sacchi, C. Bersani, F. Grassi, P. Mangiarotti, G. G. Grassi in Antimicrob Agents Chemother (1983) vol. 23 pp930-1 |
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Defective bactericidal reaction by the alternative pathway of complement in atopic patients A. G. Siccardi, A. Fortunato, M. Marconi, C. Dos Santos, F. Grassi, F. Sacchi, A. Fietta in Infect Immun (1981) vol. 33 pp710-3 |
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Serum bacterial reaction by the alternative pathway of complement: potentiation by target multiplicity and modulation by serum factors A. Fietta, A. Fortunato, C. Dos Santos, F. Grassi, A. G. Siccardi in Infect Immun (1981) vol. 33 pp704-9 |