Antonio Lanzavecchia
Immune Regulation
Director
Via Vela, 6
6500 Bellinzona,
Switzerland
- lanzavecchia@irb.usi.ch
- +41 91 820 0310
- +41 91 820 0305
| Bio |
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Antonio Lanzavecchia earned a degree in Medicine at the University of Pavia where he specialized in Paediatrics and in Infectious Diseases. From 1983 to 1999, he was a Member of the Basel Institute for Immunology and since 1999 he is the founding Director of the Institute for Research in Biomedicine in Bellinzona. He has been teaching at the University of Genoa and Siena and since 2009 is Professor of Human Immunology at the Swiss Federal Institute of Technology Zurich. He is Member of the European Molecular Biology Organization (EMBO) and Fellow of the Royal College of Physicians. Awarded the EMBO medal in 1988 and the Cloëtta prize in 1999, Antonio Lanzavecchia has published more than 250 papers. His research has covered several aspects of human immunology: from antigen processing and presentation to dendritic cell biology and from lymphocyte activation and trafficking to T and B cell memory. |
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Systems Analysis of MVA-C Induced Immune Response Reveals Its Significance as a Vaccine Candidate against HIV/AIDS of Clade C C. E. Gomez, B. Perdiguero, V. Jimenez, A. Filali-Mouhim, K. Ghneim, E. K. Haddad, E. D. Quakkerlaar, J. Delaloye, A. Harari, T. Roger, T. Dunhen, R. P. Sekaly, C. J. Melief, T. Calandra, F. Sallusto, A. Lanzavecchia, R. Wagner, G. Pantaleo, M. Esteban in PLoS One (2012) vol. 7 ppe35485 |
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Infections and organ transplantation: new challenges for prevention and treatment--a colloquium P. A. Grossi, A. N. Costa, D. Fehily, E. A. Blumberg, M. J. Kuehnert, J. A. Fishman, M. G. Ison, R. Lattes, C. N. Kotton, D. Lilleri, A. Kabanova, A. Lanzavecchia, G. Gerna, R. R. Razonable, P. Comoli, M. Zecca, S. Basso, F. Ginevri, A. Grossi, F. P. Schena, A. Rimola, P. Burra, E. De Martin, K. I. Rodriguez-Castro, S. Fagiuoli, L. Pasulo, R. Bruno, P. Andreone, E. Loggi, F. Arena, G. Maria Rossolini, G. Sganga, V. Cozza in Transplantation (2012) vol. 93 ppS4-S39 |
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Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto in Nature (2012) vol. 484 pp514-8 |
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Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector TH cells T. Duhen, R. Duhen, A. Lanzavecchia, F. Sallusto, D. J. Campbell in Blood (2012) |
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Ralph M. Steinman 1943-2011 A. Lanzavecchia, F. Sallusto in Cell (2011) vol. 147 pp1216-7 |
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Characterization of Neutralizing Profiles in HIV-1 Infected Patients from whom the HJ16, HGN194 and HK20 mAbs were Obtained S. S. Balla-Jhagjhoorsingh, B. Willems, L. Heyndrickx, K. Vereecken, W. Janssens, M. S. Seaman, D. Corti, A. Lanzavecchia, D. Davis, G. Vanham in PLoS One (2011) vol. 6 ppe25488 |
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Memory in disguise F. Sallusto, A. Lanzavecchia in Nat Med (2011) vol. 17 pp1182-3 |
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A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, P. Collins, L. F. Haire, N. Temperton, J. P. Langedijk, J. J. Skehel, A. Lanzavecchia in Science (2011) vol. 333 pp850-6 |
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In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection R. de Alwis, M. Beltramello, W. B. Messer, S. Sukupolvi-Petty, W. M. Wahala, A. Kraus, N. P. Olivarez, Q. Pham, J. Brian, W. Y. Tsai, W. K. Wang, S. Halstead, S. Kliks, M. S. Diamond, R. Baric, A. Lanzavecchia, F. Sallusto, A. M. de Silva in PLoS Negl Trop Dis (2011) vol. 5 ppe1188 |
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High throughput cellular screens to interrogate the human T and B cell repertoires D. Corti, F. Sallusto, A. Lanzavecchia in Curr Opin Immunol (2011) vol. 23 pp430-5 |
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An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV J. D. Watkins, N. B. Siddappa, S. K. Lakhashe, M. Humbert, A. Sholukh, G. Hemashettar, Y. L. Wong, J. K. Yoon, W. Wang, F. J. Novembre, F. Villinger, C. Ibegbu, K. Patel, D. Corti, G. Agatic, F. Vanzetta, S. Bianchi, J. L. Heeney, F. Sallusto, A. Lanzavecchia, R. M. Ruprecht in PLoS One (2011) vol. 6 ppe18207 |
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Dissecting the human immunologic memory for pathogens C. E. Zielinski, D. Corti, F. Mele, D. Pinto, A. Lanzavecchia, F. Sallusto in Immunol Rev (2011) vol. 240 pp40-51 |
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Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors E. D. Quakkelaar, A. Redeker, E. K. Haddad, A. Harari, S. M. McCaughey, T. Duhen, A. Filali-Mouhim, J. P. Goulet, N. M. Loof, F. Ossendorp, B. Perdiguero, P. Heinen, C. E. Gomez, K. V. Kibler, D. M. Koelle, R. P. Sekaly, F. Sallusto, A. Lanzavecchia, G. Pantaleo, M. Esteban, J. Tartaglia, B. L. Jacobs, C. J. Melief in PLoS One (2011) vol. 6 ppe16819 |
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Strain-Transcending Fc-Dependent Killing of Plasmodium falciparum by Merozoite Surface Protein 2 Allele-Specific Human Antibodies J. Stubbs, S. Olugbile, B. Saidou, J. Simpore, G. Corradin, A. Lanzavecchia in Infect Immun (2011) vol. 79 pp1143-52 |
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Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41 C. Sabin, D. Corti, V. Buzon, M. S. Seaman, D. Lutje Hulsik, A. Hinz, F. Vanzetta, G. Agatic, C. Silacci, L. Mainetti, G. Scarlatti, F. Sallusto, R. Weiss, A. Lanzavecchia, W. Weissenhorn in PLoS Pathog (2010) vol. 6 ppe1001195 |
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CD4(+) CD25(+) Treg regulate the contribution of CD8(+) T-cell subsets in repopulation of the lymphopenic environment A. R. Almeida, I. F. Ciernik, F. Sallusto, A. Lanzavecchia in Eur J Immunol (2010) vol. 40 pp3478-88 |
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Chondroitin Sulfate A-Adhering Plasmodium falciparum-Infected Erythrocytes Express Functionally Important Antibody Epitopes Shared by Multiple Variants L. Barfod, T. Dobrilovic, P. Magistrado, P. Khunrae, F. Viwami, J. Bruun, M. Dahlback, N. L. Bernasconi, M. Fried, D. John, P. E. Duffy, A. Salanti, A. Lanzavecchia, C. T. Lim, N. T. Ndam, M. K. Higgins, L. Hviid in J Immunol (2010) vol. 185 pp7553-61 |
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From vaccines to memory and back F. Sallusto, A. Lanzavecchia, K. Araki, R. Ahmed in Immunity (2010) vol. 33 pp451-63 |
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Monocytes join the dendritic cell family F. Sallusto, A. Lanzavecchia in Cell (2010) vol. 143 pp339-40 |
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The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity M. Beltramello, K. L. Williams, C. P. Simmons, A. Macagno, L. Simonelli, N. T. Quyen, S. Sukupolvi-Petty, E. Navarro-Sanchez, P. R. Young, A. M. de Silva, F. A. Rey, L. Varani, S. S. Whitehead, M. S. Diamond, E. Harris, A. Lanzavecchia, F. Sallusto in Cell Host Microbe (2010) vol. 8 pp271-83 |
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Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness J. Pietzsch, J. F. Scheid, H. Mouquet, F. Klein, M. S. Seaman, M. Jankovic, D. Corti, A. Lanzavecchia, M. C. Nussenzweig in J Exp Med (2010) vol. 207 pp1995-2002 |
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Current Opinion in Immunology. Vaccines. Introduction H. C. Ertl, A. Lanzavecchia in Curr Opin Immunol (2010) vol. 22 pp355-7 |
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Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine D. Corti, A. L. Suguitan, D. Pinna, C. Silacci, B. M. Fernandez-Rodriguez, F. Vanzetta, C. Santos, C. J. Luke, F. J. Torres-Velez, N. J. Temperton, R. A. Weiss, F. Sallusto, K. Subbarao, A. Lanzavecchia in J Clin Invest (2010) vol. 120 pp1663-73 |
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CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function L. Rivino, P. Gruarin, B. Haringer, S. Steinfelder, L. Lozza, B. Steckel, A. Weick, E. Sugliano, D. Jarrossay, A. A. Kuhl, C. Loddenkemper, S. Abrignani, F. Sallusto, A. Lanzavecchia, J. Geginat in J Exp Med (2010) vol. 207 pp565-77 |
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Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus B. Rockx, E. Donaldson, M. Frieman, T. Sheahan, D. Corti, A. Lanzavecchia, R. S. Baric in J Infect Dis (2010) vol. 201 pp946-55 |
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Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals D. Corti, J. P. Langedijk, A. Hinz, M. S. Seaman, F. Vanzetta, B. M. Fernandez-Rodriguez, C. Silacci, D. Pinna, D. Jarrossay, S. Balla-Jhagjhoorsingh, B. Willems, M. J. Zekveld, H. Dreja, E. O'Sullivan, C. Pade, C. Orkin, S. A. Jeffs, D. C. Montefiori, D. Davis, W. Weissenhorn, A. McKnight, J. L. Heeney, F. Sallusto, Q. J. Sattentau, R. A. Weiss, A. Lanzavecchia in PLoS One (2010) vol. 5 ppe8805 |
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Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex A. Macagno, N. L. Bernasconi, F. Vanzetta, E. Dander, A. Sarasini, M. G. Revello, G. Gerna, F. Sallusto, A. Lanzavecchia in J Virol (2010) vol. 84 pp1005-13 |
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Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity F. Sallusto, A. Lanzavecchia in Eur J Immunol (2009) vol. 39 pp2076-82 |
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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells T. Duhen, R. Geiger, D. Jarrossay, A. Lanzavecchia, F. Sallusto in Nat Immunol (2009) vol. 10 pp857-63 |
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Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells R. Geiger, T. Duhen, A. Lanzavecchia, F. Sallusto in J Exp Med (2009) vol. 206 pp1525-34 |
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Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein D. Voss, S. Pfefferle, C. Drosten, L. Stevermann, E. Traggiai, A. Lanzavecchia, S. Becker in Virol J (2009) vol. 6 pp79 |
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Human B cell memory A. Lanzavecchia, F. Sallusto in Curr Opin Immunol (2009) vol. 21 pp298-304 |
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Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens J. Soerli, L. Barfod, T. Lavstsen, N. L. Bernasconi, A. Lanzavecchia, L. Hviid in Parasite Immunol (2009) vol. 31 pp341-6 |
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Clonal dissection of the human memory B-cell repertoire following infection and vaccination D. Pinna, D. Corti, D. Jarrossay, F. Sallusto, A. Lanzavecchia in Eur J Immunol (2009) vol. 39 pp1260-70 |
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Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells G. Napolitani, E. V. Acosta-Rodriguez, A. Lanzavecchia, F. Sallusto in Eur J Immunol (2009) vol. 39 pp1301-12 |
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Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets S. Khurana, A. L. Suguitan, Y. Rivera, C. P. Simmons, A. Lanzavecchia, F. Sallusto, J. Manischewitz, L. R. King, K. Subbarao, H. Golding in PLoS Med (2009) vol. 6 ppe1000049 |
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Human Th17 cells in infection and autoimmunity F. Sallusto, A. Lanzavecchia in Microbes Infect (2009) vol. 11 pp620-4 |
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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto in Nat Immunol (2009) vol. 10 pp514-23 |
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Dendritic cell migration to peripheral lymph nodes A. Martin-Fontecha, A. Lanzavecchia, F. Sallusto in Handb Exp Pharmacol (2009) pp31-49 |
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CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection M. Cocco, C. Bellan, R. Tussiwand, D. Corti, E. Traggiai, S. Lazzi, S. Mannucci, L. Bronz, N. Palummo, C. Ginanneschi, P. Tosi, A. Lanzavecchia, M. G. Manz, L. Leoncini in Am J Pathol (2008) vol. 173 pp1369-78 |
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CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming A. Martin-Fontecha, D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, F. Sallusto in J Exp Med (2008) vol. 205 pp2561-74 |
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Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells G. De Falco, E. Leucci, A. Onnis, C. Bellan, C. Tigli, S. Wirths, G. Cerino, M. Cocco, D. Crupi, A. De Luca, A. Lanzavecchia, P. Tosi, L. Leoncini, A. Giordano in J Cell Physiol (2008) vol. 215 pp276-82 |
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Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge B. Rockx, D. Corti, E. Donaldson, T. Sheahan, K. Stadler, A. Lanzavecchia, R. Baric in J Virol (2008) vol. 82 pp3220-35 |
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The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells L. Lozza, L. Rivino, G. Guarda, D. Jarrossay, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia, J. Geginat in Eur J Immunol (2008) vol. 38 pp30-9 |
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Human monoclonal antibodies by immortalization of memory B cells A. Lanzavecchia, D. Corti, F. Sallusto in Curr Opin Biotechnol (2007) vol. 18 pp523-8 |
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Pillars article: Antigen-specific interaction between T and B cells. 1985 A. Lanzavecchia in J Immunol (2007) vol. 179 pp7206-8 |
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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto in Nat Immunol (2007) vol. 8 pp942-9 |
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Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate S. L. Reiner, F. Sallusto, A. Lanzavecchia in Science (2007) vol. 317 pp622-5 |
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Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Z. Zhu, S. Chakraborti, Y. He, A. Roberts, T. Sheahan, X. Xiao, L. E. Hensley, P. Prabakaran, B. Rockx, I. A. Sidorov, D. Corti, L. Vogel, Y. Feng, J. O. Kim, L. F. Wang, R. Baric, A. Lanzavecchia, K. M. Curtis, G. J. Nabel, K. Subbarao, S. Jiang, D. S. Dimitrov in Proc Natl Acad Sci U S A (2007) vol. 104 pp12123-8 |
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Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza C. P. Simmons, N. L. Bernasconi, A. L. Suguitan, K. Mills, J. M. Ward, N. V. Chau, T. T. Hien, F. Sallusto, Q. Ha do, J. Farrar, M. D. de Jong, A. Lanzavecchia, K. Subbarao in PLoS Med (2007) vol. 4 ppe178 |
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L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells G. Guarda, M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martin-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, F. Sallusto in Nat Immunol (2007) vol. 8 pp743-52 |
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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells E. V. Acosta-Rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, G. Napolitani in Nat Immunol (2007) vol. 8 pp639-46 |
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Toll-like receptors and innate immunity in B-cell activation and antibody responses A. Lanzavecchia, F. Sallusto in Curr Opin Immunol (2007) vol. 19 pp268-74 |
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Duration, combination and timing: the signal integration model of dendritic cell activation A. Macagno, G. Napolitani, A. Lanzavecchia, F. Sallusto in Trends Immunol (2007) vol. 28 pp227-33 |
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Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA L. Barfod, N. L. Bernasconi, M. Dahlback, D. Jarrossay, P. H. Andersen, A. Salanti, M. F. Ofori, L. Turner, M. Resende, M. A. Nielsen, T. G. Theander, F. Sallusto, A. Lanzavecchia, L. Hviid in Mol Microbiol (2007) vol. 63 pp335-47 |
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Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue M. Gattorno, L. Chicha, A. Gregorio, F. Ferlito, F. Rossi, D. Jarrossay, A. Lanzavecchia, A. Martini, M. G. Manz in Rheumatology (Oxford) (2007) vol. 46 pp657-65 |
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Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases R. Ghittoni, G. Napolitani, D. Benati, C. Ulivieri, L. Patrussi, F. Laghi Pasini, A. Lanzavecchia, C. T. Baldari in Eur J Immunol (2006) vol. 36 pp2885-93 |
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Understanding and making use of human memory B cells A. Lanzavecchia, N. Bernasconi, E. Traggiai, C. R. Ruprecht, D. Corti, F. Sallusto in Immunol Rev (2006) vol. 211 pp303-9 |
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A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression A. Macagno, M. Molteni, A. Rinaldi, F. Bertoni, A. Lanzavecchia, C. Rossetti, F. Sallusto in J Exp Med (2006) vol. 203 pp1481-92 |
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Toll-like receptor stimulation as a third signal required for activation of human naive B cells C. R. Ruprecht, A. Lanzavecchia in Eur J Immunol (2006) vol. 36 pp810-6 |
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Regulation of peripheral T cell activation by calreticulin S. Porcellini, E. Traggiai, U. Schenk, D. Ferrera, M. Matteoli, A. Lanzavecchia, M. Michalak, F. Grassi in J Exp Med (2006) vol. 203 pp461-71 |
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Characterization of severe acute respiratory syndrome coronavirus membrane protein D. Voss, A. Kern, E. Traggiai, M. Eickmann, K. Stadler, A. Lanzavecchia, S. Becker in FEBS Lett (2006) vol. 580 pp968-73 |
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Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development N. Onai, A. Obata-Onai, R. Tussiwand, A. Lanzavecchia, M. G. Manz in J Exp Med (2006) vol. 203 pp227-38 |
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ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells S. Wirths, A. Lanzavecchia in Eur J Immunol (2005) vol. 35 pp3433-41 |
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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells G. Napolitani, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia in Nat Immunol (2005) vol. 6 pp769-76 |
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Human adaptive immune system Rag2-/-gamma(c)-/- mice L. Chicha, R. Tussiwand, E. Traggiai, L. Mazzucchelli, L. Bronz, J. C. Piffaretti, A. Lanzavecchia, M. G. Manz in Ann N Y Acad Sci (2005) vol. 1044 pp236-43 |
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Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia C. R. Ruprecht, M. Gattorno, F. Ferlito, A. Gregorio, A. Martini, A. Lanzavecchia, F. Sallusto in J Exp Med (2005) vol. 201 pp1793-803 |
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Understanding the generation and function of memory T cell subsets A. Lanzavecchia, F. Sallusto in Curr Opin Immunol (2005) vol. 17 pp326-32 |
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T cell costimulation by chemokine receptors B. Molon, G. Gri, M. Bettella, C. Gomez-Mouton, A. Lanzavecchia, A. C. Martinez, S. Manes, A. Viola in Nat Immunol (2005) vol. 6 pp465-71 |
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Immune subversion by Helicobacter pylori C. T. Baldari, A. Lanzavecchia, J. L. Telford in Trends Immunol (2005) vol. 26 pp199-207 |
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Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses Z. Y. Yang, H. C. Werner, W. P. Kong, K. Leung, E. Traggiai, A. Lanzavecchia, G. J. Nabel in Proc Natl Acad Sci U S A (2005) vol. 102 pp797-801 |
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Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice S. Feau, V. Facchinetti, F. Granucci, S. Citterio, D. Jarrossay, S. Seresini, M. P. Protti, A. Lanzavecchia, P. Ricciardi-Castagnoli in Blood (2005) vol. 105 pp697-702 |
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Lead and follow: the dance of the dendritic cell and T cell A. Lanzavecchia, F. Sallusto in Nat Immunol (2004) vol. 5 pp1201-2 |
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Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming A. Martin-Fontecha, L. L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, F. Sallusto in Nat Immunol (2004) vol. 5 pp1260-5 |
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Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells L. Rivino, M. Messi, D. Jarrossay, A. Lanzavecchia, F. Sallusto, J. Geginat in J Exp Med (2004) vol. 200 pp725-35 |
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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus E. Traggiai, S. Becker, K. Subbarao, L. Kolesnikova, Y. Uematsu, M. R. Gismondo, B. R. Murphy, R. Rappuoli, A. Lanzavecchia in Nat Med (2004) vol. 10 pp871-5 |
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Development of a human adaptive immune system in cord blood cell-transplanted mice E. Traggiai, L. Chicha, L. Mazzucchelli, L. Bronz, J. C. Piffaretti, A. Lanzavecchia, M. G. Manz in Science (2004) vol. 304 pp104-7 |
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Central memory and effector memory T cell subsets: function, generation, and maintenance F. Sallusto, J. Geginat, A. Lanzavecchia in Annu Rev Immunol (2004) vol. 22 pp745-63 |
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Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation G. Napolitani, N. Bortoletto, L. Racioppi, A. Lanzavecchia, U. D'Oro in Eur J Immunol (2003) vol. 33 pp2832-41 |
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Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming A. Martin-Fontecha, S. Sebastiani, U. E. Hopken, M. Uguccioni, M. Lipp, A. Lanzavecchia, F. Sallusto in J Exp Med (2003) vol. 198 pp615-21 |
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Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells J. Geginat, F. Sallusto, A. Lanzavecchia in Pathol Biol (Paris) (2003) vol. 51 pp64-6 |
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Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors D. Hanahan, A. Lanzavecchia, E. Mihich in Cancer Res (2003) vol. 63 pp3005-8 |
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Antigen dependent and independent mechanisms that sustain serum antibody levels E. Traggiai, R. Puzone, A. Lanzavecchia in Vaccine (2003) vol. 21 Suppl 2 ppS35-7 |
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Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells A. Langenkamp, K. Nagata, K. Murphy, L. Wu, A. Lanzavecchia, F. Sallusto in Eur J Immunol (2003) vol. 33 pp474-82 |
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T cell fitness determined by signal strength A. V. Gett, F. Sallusto, A. Lanzavecchia, J. Geginat in Nat Immunol (2003) vol. 4 pp355-60 |
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Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines J. Geginat, A. Lanzavecchia, F. Sallusto in Blood (2003) vol. 101 pp4260-6 |
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A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells N. L. Bernasconi, N. Onai, A. Lanzavecchia in Blood (2003) vol. 101 pp4500-4 |
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Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes M. Messi, I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, F. Sallusto in Nat Immunol (2003) vol. 4 pp78-86 |
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Maintenance of serological memory by polyclonal activation of human memory B cells N. L. Bernasconi, E. Traggiai, A. Lanzavecchia in Science (2002) vol. 298 pp2199-202 |
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A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding J. Rachmilewitz, A. Lanzavecchia in Trends Immunol (2002) vol. 23 pp592-5 |
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Progressive differentiation and selection of the fittest in the immune response A. Lanzavecchia, F. Sallusto in Nat Rev Immunol (2002) vol. 2 pp982-7 |
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TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines J. Geginat, S. Campagnaro, F. Sallusto, A. Lanzavecchia in Adv Exp Med Biol (2002) vol. 512 pp107-12 |
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Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells N. Bortoletto, E. Scotet, Y. Myamoto, U. D'Oro, A. Lanzavecchia in Eur J Immunol (2002) vol. 32 pp3102-7 |
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T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification A. Langenkamp, G. Casorati, C. Garavaglia, P. Dellabona, A. Lanzavecchia, F. Sallusto in Eur J Immunol (2002) vol. 32 pp2046-54 |
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The instructive role of dendritic cells on T-cell responses F. Sallusto, A. Lanzavecchia in Arthritis Res (2002) vol. 4 Suppl 3 ppS127-32 |
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Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes H. Yoneyama, S. Narumi, Y. Zhang, M. Murai, M. Baggiolini, A. Lanzavecchia, T. Ichida, H. Asakura, K. Matsushima in J Exp Med (2002) vol. 195 pp1257-66 |
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The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells A. Engering, T. B. Geijtenbeek, S. J. van Vliet, M. Wijers, E. van Liempt, N. Demaurex, A. Lanzavecchia, J. Fransen, C. G. Figdor, V. Piguet, Y. van Kooyk in J Immunol (2002) vol. 168 pp2118-26 |
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Lack of fair play in the T cell response A. Lanzavecchia in Nat Immunol (2002) vol. 3 pp9-10 |
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BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction A. Dzionek, Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Gunther, I. Johnston, A. Lanzavecchia, T. Nagasaka, T. Okada, W. Vermi, G. Winkels, T. Yamamoto, M. Zysk, Y. Yamaguchi, J. Schmitz in J Exp Med (2001) vol. 194 pp1823-34 |
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Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells J. Geginat, F. Sallusto, A. Lanzavecchia in J Exp Med (2001) vol. 194 pp1711-9 |
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Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8alpha(+) and CD8alpha(-) dendritic cells L. Bruno, T. Seidl, A. Lanzavecchia in Eur J Immunol (2001) vol. 31 pp3403-12 |
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Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells D. Jarrossay, G. Napolitani, M. Colonna, F. Sallusto, A. Lanzavecchia in Eur J Immunol (2001) vol. 31 pp3388-93 |
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Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells E. Scotet, S. Schroeder, A. Lanzavecchia in Blood (2001) vol. 98 pp2568-70 |
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Exploring pathways for memory T cell generation F. Sallusto, A. Lanzavecchia in J Clin Invest (2001) vol. 108 pp805-6 |
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Regulation of T cell immunity by dendritic cells A. Lanzavecchia, F. Sallusto in Cell (2001) vol. 106 pp263-6 |
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The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics A. Lanzavecchia, F. Sallusto in Curr Opin Immunol (2001) vol. 13 pp291-8 |
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Antigen decoding by T lymphocytes: from synapses to fate determination A. Lanzavecchia, F. Sallusto in Nat Immunol (2001) vol. 2 pp487-92 |
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Migration and function of antigen-primed nonpolarized T lymphocytes in vivo G. Iezzi, D. Scheidegger, A. Lanzavecchia in J Exp Med (2001) vol. 193 pp987-93 |
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Organization of plasma membrane functional rafts upon T cell activation L. Tuosto, I. Parolini, S. Schroder, M. Sargiacomo, A. Lanzavecchia, A. Viola in Eur J Immunol (2001) vol. 31 pp345-9 |
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Antigen processing and recognition P. Cresswell, A. Lanzavecchia in Curr Opin Immunol (2001) vol. 13 pp11-2 |
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Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells A. Langenkamp, M. Messi, A. Lanzavecchia, F. Sallusto in Nat Immunol (2000) vol. 1 pp311-6 |
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Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization M. Cella, F. Facchetti, A. Lanzavecchia, M. Colonna in Nat Immunol (2000) vol. 1 pp305-10 |
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Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression F. Sallusto, A. Lanzavecchia in Immunol Rev (2000) vol. 177 pp134-40 |
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A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response P. R. Dunbar, C. L. Smith, D. Chao, M. Salio, D. Shepherd, F. Mirza, M. Lipp, A. Lanzavecchia, F. Sallusto, A. Evans, R. Russell-Jones, A. L. Harris, V. Cerundolo in J Immunol (2000) vol. 165 pp6644-52 |
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Functional subsets of memory T cells identified by CCR7 expression F. Sallusto, A. Langenkamp, J. Geginat, A. Lanzavecchia in Curr Top Microbiol Immunol (2000) vol. 251 pp167-71 |
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Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells A. Lanzavecchia, F. Sallusto in Science (2000) vol. 290 pp92-7 |
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Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming M. C. Gagliardi, F. Sallusto, M. Marinaro, A. Langenkamp, A. Lanzavecchia, M. T. De Magistris in Eur J Immunol (2000) vol. 30 pp2394-403 |
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The role of chemokine receptors in primary, effector, and memory immune responses F. Sallusto, C. R. Mackay, A. Lanzavecchia in Annu Rev Immunol (2000) vol. 18 pp593-620 |
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Cutting edge: recombinase-activating gene expression and V(D)J recombination in CD4+CD3low mature T lymphocytes E. Lantelme, B. Palermo, L. Granziero, S. Mantovani, R. Campanelli, V. Monafo, A. Lanzavecchia, C. Giachino in J Immunol (2000) vol. 164 pp3455-9 |
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The role of aquaporins in dendritic cell macropinocytosis A. de Baey, A. Lanzavecchia in J Exp Med (2000) vol. 191 pp743-8 |
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From synapses to immunological memory: the role of sustained T cell stimulation A. Lanzavecchia, F. Sallusto in Curr Opin Immunol (2000) vol. 12 pp92-8 |
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Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells M. Salio, V. Cerundolo, A. Lanzavecchia in Eur J Immunol (2000) vol. 30 pp705-8 |
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Three signals and a master switch in the regulation of T-cell immunity A. Lanzavecchia in Cold Spring Harb Symp Quant Biol (1999) vol. 64 pp253-7 |
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Dendritic cell maturation and generation of immune responses A. Lanzavecchia in Haematologica (1999) vol. 84 Suppl EHA-4 pp23-5 |
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Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation A. Macagno, M. Gilliet, F. Sallusto, A. Lanzavecchia, F. O. Nestle, M. Groettrup in Eur J Immunol (1999) vol. 29 pp4037-42 |
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The interplay between the duration of TCR and cytokine signaling determines T cell polarization G. Iezzi, E. Scotet, D. Scheidegger, A. Lanzavecchia in Eur J Immunol (1999) vol. 29 pp4092-101 |
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Inhibition of dendritic cell maturation by herpes simplex virus M. Salio, M. Cella, M. Suter, A. Lanzavecchia in Eur J Immunol (1999) vol. 29 pp3245-53 |
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions F. Sallusto, D. Lenig, R. Forster, M. Lipp, A. Lanzavecchia in Nature (1999) vol. 401 pp708-12 |
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T-cell activation and the dynamic world of rafts A. Viola, A. Lanzavecchia in APMIS (1999) vol. 107 pp615-23 |
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Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon M. Cella, D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, M. Colonna in Nat Med (1999) vol. 5 pp919-23 |
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The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells F. Sallusto, B. Palermo, A. Hoy, A. Lanzavecchia in Curr Top Microbiol Immunol (1999) vol. 246 pp123-8; discussion 129 |
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Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells F. Sallusto, E. Kremmer, B. Palermo, A. Hoy, P. Ponath, S. Qin, R. Forster, M. Lipp, A. Lanzavecchia in Eur J Immunol (1999) vol. 29 pp2037-45 |
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Distinct patterns and kinetics of chemokine production regulate dendritic cell function F. Sallusto, B. Palermo, D. Lenig, M. Miettinen, S. Matikainen, I. Julkunen, R. Forster, R. Burgstahler, M. Lipp, A. Lanzavecchia in Eur J Immunol (1999) vol. 29 pp1617-25 |
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Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells M. F. Bachmann, A. Gallimore, S. Linkert, V. Cerundolo, A. Lanzavecchia, M. Kopf, A. Viola in J Exp Med (1999) vol. 189 pp1521-30 |
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Maturation, activation, and protection of dendritic cells induced by double-stranded RNA M. Cella, M. Salio, Y. Sakakibara, H. Langen, I. Julkunen, A. Lanzavecchia in J Exp Med (1999) vol. 189 pp821-9 |
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Mobilizing dendritic cells for tolerance, priming, and chronic inflammation F. Sallusto, A. Lanzavecchia in J Exp Med (1999) vol. 189 pp611-4 |
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From TCR engagement to T cell activation: a kinetic view of T cell behavior A. Lanzavecchia, G. Lezzi, A. Viola in Cell (1999) vol. 96 pp1-4 |
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T lymphocyte costimulation mediated by reorganization of membrane microdomains A. Viola, S. Schroeder, Y. Sakakibara, A. Lanzavecchia in Science (1999) vol. 283 pp680-2 |
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Peptide binding and editing: generation of TCR ligands G. J. Hammerling, B. Manoury, C. Watts, L. Adorini, A. Lanzavecchia in Res Immunol (1998) vol. 149 pp863-5 |
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Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses F. Sallusto, A. Lanzavecchia, C. R. Mackay in Immunol Today (1998) vol. 19 pp568-74 |
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From antigen presentation to T-cell activation A. Lanzavecchia in Res Immunol (1998) vol. 149 pp626 |
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Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes C. Giachino, E. Padovan, A. Lanzavecchia in Eur J Immunol (1998) vol. 28 pp3506-13 |
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Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation F. Sallusto, P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C. R. Mackay, S. Qin, A. Lanzavecchia in Eur J Immunol (1998) vol. 28 pp2760-9 |
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Immunology. Licence to kill A. Lanzavecchia in Nature (1998) vol. 393 pp413-4 |
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Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes F. Sallusto, D. Lenig, C. R. Mackay, A. Lanzavecchia in J Exp Med (1998) vol. 187 pp875-83 |
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The duration of antigenic stimulation determines the fate of naive and effector T cells G. Iezzi, K. Karjalainen, A. Lanzavecchia in Immunity (1998) vol. 8 pp89-95 |
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Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA M. Molinari, M. Salio, C. Galli, N. Norais, R. Rappuoli, A. Lanzavecchia, C. Montecucco in J Exp Med (1998) vol. 187 pp135-40 |
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Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering A. Viola, M. Salio, L. Tuosto, S. Linkert, O. Acuto, A. Lanzavecchia in J Exp Med (1997) vol. 186 pp1775-9 |
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A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies A. Viola, S. Linkert, A. Lanzavecchia in Eur J Immunol (1997) vol. 27 pp3080-3 |
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The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells A. J. Engering, M. Cella, D. Fluitsma, M. Brockhaus, E. C. Hoefsmit, A. Lanzavecchia, J. Pieters in Eur J Immunol (1997) vol. 27 pp2417-25 |
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Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells F. Sallusto, C. R. Mackay, A. Lanzavecchia in Science (1997) vol. 277 pp2005-7 |
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Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells M. Cella, A. Engering, V. Pinet, J. Pieters, A. Lanzavecchia in Nature (1997) vol. 388 pp782-7 |
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CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis C. Caux, C. Massacrier, B. Vanbervliet, B. Dubois, I. Durand, M. Cella, A. Lanzavecchia, J. Banchereau in Blood (1997) vol. 90 pp1458-70 |
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Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation M. Salio, S. Valitutti, A. Lanzavecchia in Eur J Immunol (1997) vol. 27 pp1769-73 |
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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition S. Valitutti, A. Lanzavecchia in Immunol Today (1997) vol. 18 pp299-304 |
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A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing M. Cella, C. Dohring, J. Samaridis, M. Dessing, M. Brockhaus, A. Lanzavecchia, M. Colonna in J Exp Med (1997) vol. 185 pp1743-51 |
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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation S. Valitutti, S. Muller, M. Salio, A. Lanzavecchia in J Exp Med (1997) vol. 185 pp1859-64 |
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Understanding the mechanisms of sustained signaling and T cell activation A. Lanzavecchia in J Exp Med (1997) vol. 185 pp1717-9 |
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Baculovirus cDNA libraries for expression cloning of genes encoding cell-surface antigens L. Granziero, P. Nelboeck, M. Bedoucha, A. Lanzavecchia, H. H. Reid in J Immunol Methods (1997) vol. 203 pp131-9 |
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Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients S. Uccini, M. C. Sirianni, L. Vincenzi, S. Topino, A. Stoppacciaro, I. Lesnoni La Parola, M. Capuano, C. Masini, D. Cerimele, M. Cella, A. Lanzavecchia, P. Allavena, A. Mantovani, C. D. Baroni, L. P. Ruco in Am J Pathol (1997) vol. 150 pp929-38 |
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Origin, maturation and antigen presenting function of dendritic cells M. Cella, F. Sallusto, A. Lanzavecchia in Curr Opin Immunol (1997) vol. 9 pp10-6 |
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Mannose receptor mediated antigen uptake and presentation in human dendritic cells A. J. Engering, M. Cella, D. M. Fluitsma, E. C. Hoefsmit, A. Lanzavecchia, J. Pieters in Adv Exp Med Biol (1997) vol. 417 pp183-7 |
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Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients M. Vavassori, R. Maccario, A. Moretta, P. Comoli, A. Wack, F. Locatelli, A. Lanzavecchia, E. Maserati, P. Dellabona, G. Casorati, D. Montagna in J Immunol (1996) vol. 157 pp5739-47 |
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Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates S. Valitutti, S. Muller, M. Dessing, A. Lanzavecchia in Eur J Immunol (1996) vol. 26 pp2012-6 |
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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation M. Cella, D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, G. Alber in J Exp Med (1996) vol. 184 pp747-52 |
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T cell activation determined by T cell receptor number and tunable thresholds A. Viola, A. Lanzavecchia in Science (1996) vol. 273 pp104-6 |
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Mechanisms of antigen uptake for presentation A. Lanzavecchia in Curr Opin Immunol (1996) vol. 8 pp348-54 |
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Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy S. Valitutti, S. Muller, M. Dessing, A. Lanzavecchia in J Exp Med (1996) vol. 183 pp1917-21 |
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Presentation of peptides by cultured monocytes or activated T cells allows specific priming of human cytotoxic T lymphocytes in vitro M. C. Gagliardi, G. De Petrillo, S. Salemi, L. Boffa, M. G. Longobardi, P. Dellabona, G. Casorati, N. Tanigaki, R. Harris, A. Lanzavecchia, et al. in Int Immunol (1995) vol. 7 pp1741-52 |
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Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines S. Sozzani, F. Sallusto, W. Luini, D. Zhou, L. Piemonti, P. Allavena, J. Van Damme, S. Valitutti, A. Lanzavecchia, A. Mantovani in J Immunol (1995) vol. 155 pp3292-5 |
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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products F. Sallusto, M. Cella, C. Danieli, A. Lanzavecchia in J Exp Med (1995) vol. 182 pp389-400 |
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Dual receptor T-cells. Implications for alloreactivity and autoimmunity E. Padovan, G. Casorati, P. Dellabona, C. Giachino, A. Lanzavecchia in Ann N Y Acad Sci (1995) vol. 756 pp66-70 |
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CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation P. Lane, C. Burdet, F. McConnell, A. Lanzavecchia, E. Padovan in Eur J Immunol (1995) vol. 25 pp1788-93 |
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How can cryptic epitopes trigger autoimmunity? A. Lanzavecchia in J Exp Med (1995) vol. 181 pp1945-8 |
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Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants P. D. Simitsek, D. G. Campbell, A. Lanzavecchia, N. Fairweather, C. Watts in J Exp Med (1995) vol. 181 pp1957-63 |
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Serial triggering of many T-cell receptors by a few peptide-MHC complexes S. Valitutti, S. Muller, M. Cella, E. Padovan, A. Lanzavecchia in Nature (1995) vol. 375 pp148-51 |
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Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion E. Padovan, C. Giachino, M. Cella, S. Valitutti, O. Acuto, A. Lanzavecchia in J Exp Med (1995) vol. 181 pp1587-91 |
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kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire C. Giachino, E. Padovan, A. Lanzavecchia in J Exp Med (1995) vol. 181 pp1245-50 |
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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton S. Valitutti, M. Dessing, K. Aktories, H. Gallati, A. Lanzavecchia in J Exp Med (1995) vol. 181 pp577-84 |
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T cell epitope analysis with peptides simultaneously synthesized on cellulose membranes: fine mapping of two DQ dependent epitopes S. Adler, R. Frank, A. Lanzavecchia, S. Weiss in FEBS Lett (1994) vol. 352 pp167-70 |
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Peptide partners call the tune A. Lanzavecchia, C. Watts in Nature (1994) vol. 371 pp198-9 |
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An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells P. Dellabona, E. Padovan, G. Casorati, M. Brockhaus, A. Lanzavecchia in J Exp Med (1994) vol. 180 pp1171-6 |
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Clonal expansions of V delta 1+ and V delta 2+ cells increase with age and limit the repertoire of human gamma delta T cells C. Giachino, L. Granziero, V. Modena, V. Maiocco, C. Lomater, F. Fantini, A. Lanzavecchia, N. Migone in Eur J Immunol (1994) vol. 24 pp1914-8 |
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T-helper- and accessory-cell-independent cytotoxic responses to human tumor cells transfected with a B7 retroviral vector C. Dohring, L. Angman, G. Spagnoli, A. Lanzavecchia in Int J Cancer (1994) vol. 57 pp754-9 |
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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha F. Sallusto, A. Lanzavecchia in J Exp Med (1994) vol. 179 pp1109-18 |
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Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles D. Valmori, A. Sabbatini, A. Lanzavecchia, G. Corradin, P. M. Matricardi in J Immunol (1994) vol. 152 pp2921-9 |
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Professional presentation of antigen by activated human T cells V. Barnaba, C. Watts, M. de Boer, P. Lane, A. Lanzavecchia in Eur J Immunol (1994) vol. 24 pp71-5 |
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Expression of two T cell receptor alpha chains: dual receptor T cells E. Padovan, G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, A. Lanzavecchia in Science (1993) vol. 262 pp422-4 |
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Suppressive effect of antibody on processing of T cell epitopes C. Watts, A. Lanzavecchia in J Exp Med (1993) vol. 178 pp1459-63 |
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Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1 P. Lane, W. Gerhard, S. Hubele, A. Lanzavecchia, F. McConnell in Immunology (1993) vol. 80 pp56-61 |
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In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset P. Dellabona, G. Casorati, B. Friedli, L. Angman, F. Sallusto, A. Tunnacliffe, E. Roosneek, A. Lanzavecchia in J Exp Med (1993) vol. 177 pp1763-71 |
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Identifying strategies for immune intervention A. Lanzavecchia in Science (1993) vol. 260 pp937-44 |
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Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility S. Valitutti, M. Dessing, A. Lanzavecchia in Eur J Immunol (1993) vol. 23 pp790-5 |
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Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation P. Lane, T. Brocker, S. Hubele, E. Padovan, A. Lanzavecchia, F. McConnell in J Exp Med (1993) vol. 177 pp1209-13 |
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The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86 S. Demotz, C. Barbey, G. Corradin, A. Amoroso, A. Lanzavecchia in Eur J Immunol (1993) vol. 23 pp425-32 |
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Presentation of self-peptides: consequences for self nonself discrimination and allorecognition S. Demotz, A. Lanzavecchia in Int Rev Immunol (1993) vol. 10 pp321-6 |
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Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen P. Panina-Bordignon, X. T. Fu, A. Lanzavecchia, R. W. Karr in J Exp Med (1992) vol. 176 pp1779-84 |
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Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes P. Lane, A. Traunecker, S. Hubele, S. Inui, A. Lanzavecchia, D. Gray in Eur J Immunol (1992) vol. 22 pp2573-8 |
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T cell clones with normal or defective O-galactosylation from a patient with permanent mixed-field polyagglutinability M. Thurnher, H. Clausen, W. Fierz, A. Lanzavecchia, E. G. Berger in Eur J Immunol (1992) vol. 22 pp1835-42 |
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Irreversible association of peptides with class II MHC molecules in living cells A. Lanzavecchia, P. A. Reid, C. Watts in Nature (1992) vol. 357 pp249-52 |
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Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition B. Boitel, M. Ermonval, P. Panina-Bordignon, R. A. Mariuzza, A. Lanzavecchia, O. Acuto in J Exp Med (1992) vol. 175 pp765-77 |
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Adoptive immunotherapy of ovarian carcinoma with bs-MAb-targeted lymphocytes: a multicenter study R. L. Bolhuis, C. H. Lamers, S. H. Goey, A. M. Eggermont, J. B. Trimbos, G. Stoter, A. Lanzavecchia, E. di Re, S. Miotti, F. Raspagliesi, et al. in Int J Cancer Suppl (1992) vol. 7 pp78-81 |
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Janusin: new molecular design for bispecific reagents A. Traunecker, A. Lanzavecchia, K. Karjalainen in Int J Cancer Suppl (1992) vol. 7 pp51-2 |
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Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells A. Traunecker, A. Lanzavecchia, K. Karjalainen in EMBO J (1991) vol. 10 pp3655-9 |
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Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes H. W. Davidson, P. A. Reid, A. Lanzavecchia, C. Watts in Cell (1991) vol. 67 pp105-16 |
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Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions R. W. Karr, P. Panina-Bordignon, W. Y. Yu, A. Lanzavecchia in J Immunol (1991) vol. 146 pp4242-7 |
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Recognition by class II alloreactive T cells of processed determinants from human serum proteins P. Panina-Bordignon, G. Corradin, E. Roosnek, A. Sette, A. Lanzavecchia in Science (1991) vol. 252 pp1548-50 |
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Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cells G. De Libero, G. Casorati, C. Giachino, C. Carbonara, N. Migone, P. Matzinger, A. Lanzavecchia in J Exp Med (1991) vol. 173 pp1311-22 |
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Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells E. Roosnek, A. Lanzavecchia in J Exp Med (1991) vol. 173 pp487-9 |
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Chemical and functional analysis of MHC class II-restricted T cell epitopes C. Corradin, A. Lanzavecchia in Int Rev Immunol (1991) vol. 7 pp139-47 |
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Correlation between TCR V gene usage and antigen specificities in human gamma delta T cells G. De Libero, G. Casorati, N. Migone, A. Lanzavecchia in Curr Top Microbiol Immunol (1991) vol. 173 pp235-8 |
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New perspectives on immunointervention in autoimmune diseases L. Adorini, V. Barnaba, C. Bona, F. Celada, A. Lanzavecchia, E. Sercarz, N. Suciu-Foca, H. Wekerle in Immunol Today (1990) vol. 11 pp383-6 |
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T cell activation by a bispecific anti-CD3/anti-major histocompatibility complex class I antibody E. Roosnek, A. Tunnacliffe, A. Lanzavecchia in Eur J Immunol (1990) vol. 20 pp1393-6 |
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Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes A. Lanzavecchia in Annu Rev Immunol (1990) vol. 8 pp773-93 |
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Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways S. Demotz, P. M. Matricardi, C. Irle, P. Panina, A. Lanzavecchia, G. Corradin in J Immunol (1989) vol. 143 pp3881-6 |
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Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells P. Panina-Bordignon, A. Tan, A. Termijtelen, S. Demotz, G. Corradin, A. Lanzavecchia in Eur J Immunol (1989) vol. 19 pp2237-42 |
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Molecular analysis of human gamma/delta+ clones from thymus and peripheral blood G. Casorati, G. De Libero, A. Lanzavecchia, N. Migone in J Exp Med (1989) vol. 170 pp1521-35 |
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A novel and simple procedure for determining T cell epitopes in protein antigens S. Demotz, P. Matricardi, A. Lanzavecchia, G. Corradin in J Immunol Methods (1989) vol. 122 pp67-72 |
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Establishment of human double-positive thymocyte clones G. De Libero, A. Lanzavecchia in J Exp Med (1989) vol. 170 pp303-8 |
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Triggering T cells by otherwise inert hybrid anti-CD3/antitumor antibodies requires encounter with the specific target cell E. Roosnek, A. Lanzavecchia in J Exp Med (1989) vol. 170 pp297-302 |
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How many ways can a killer cell kill? A. Lanzavecchia in Int Rev Immunol (1989) vol. 4 pp109-14 |
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Is suppression a function of class II--restricted cytotoxic T cells? A. Lanzavecchia in Immunol Today (1989) vol. 10 pp157-9 |
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In vivo localization of a bispecific antibody which targets human T lymphocytes to lyse human colon cancer cells I. G. Barr, S. Miescher, V. von Fliedner, F. Buchegger, C. Barras, A. Lanzavecchia, J. P. Mach, S. Carrel in Int J Cancer (1989) vol. 43 pp501-7 |
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Delineation of several DR-restricted tetanus toxin T cell epitopes S. Demotz, A. Lanzavecchia, U. Eisel, H. Niemann, C. Widmann, G. Corradin in J Immunol (1989) vol. 142 pp394-402 |
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Harming and protecting responses to HIV A. Lanzavecchia in Res Immunol (1989) vol. 140 pp99-103; discussion 123-4 |
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Study on the immunogenicity of human class-II-restricted T-cell epitopes: processing constraints, degenerate binding, and promiscuous recognition P. Panina-Bordignon, S. Demotz, G. Corradin, A. Lanzavecchia in Cold Spring Harb Symp Quant Biol (1989) vol. 54 Pt 1 pp445-51 |
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Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes O. Krahenbuhl, C. Rey, D. Jenne, A. Lanzavecchia, P. Groscurth, S. Carrel, J. Tschopp in J Immunol (1988) vol. 141 pp3471-7 |
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Clonal sketches of the immune response A. Lanzavecchia in EMBO J (1988) vol. 7 pp2945-51 |
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Activation of mononuclear cells to be used for hybrid monoclonal antibody-induced lysis of human ovarian carcinoma cells S. M. Pupa, S. Canevari, R. Fontanelli, S. Menard, D. Mezzanzanica, A. Lanzavecchia, M. I. Colnaghi in Int J Cancer (1988) vol. 42 pp455-9 |
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T cells can present antigens such as HIV gp120 targeted to their own surface molecules A. Lanzavecchia, E. Roosnek, T. Gregory, P. Berman, S. Abrignani in Nature (1988) vol. 334 pp530-2 |
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Kinetics of MHC-antigen complex formation on antigen-presenting cells E. Roosnek, S. Demotz, G. Corradin, A. Lanzavecchia in J Immunol (1988) vol. 140 pp4079-82 |
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Exploiting the immune system's own strategies for immunotherapy A. Lanzavecchia in Immunol Today (1988) vol. 9 pp167-8 |
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Human ovarian carcinoma lysis by cytotoxic T cells targeted by bispecific monoclonal antibodies: analysis of the antibody components D. Mezzanzanica, S. Canevari, S. Menard, S. M. Pupa, E. Tagliabue, A. Lanzavecchia, M. I. Colnaghi in Int J Cancer (1988) vol. 41 pp609-15 |
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Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets A. Lanzavecchia, S. Abrignani, D. Scheidegger, R. Obrist, B. Dorken, G. Moldenhauer in J Exp Med (1988) vol. 167 pp345-52 |
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Anti-ovarian carcinoma anti-T3 heteroconjugates or hybrid antibodies induce tumor cell lysis by cytotoxic T-cells S. Canevari, S. Menard, D. Mezzanzanica, S. Miotti, S. M. Pupa, A. Lanzavecchia, M. I. Colnaghi in Int J Cancer Suppl (1988) vol. 2 pp18-21 |
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Antigen uptake and accumulation in antigen-specific B cells A. Lanzavecchia in Immunol Rev (1987) vol. 99 pp39-51 |
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Lysis of nonnucleated red blood cells by cytotoxic T lymphocytes A. Lanzavecchia, U. D. Staerz in Eur J Immunol (1987) vol. 17 pp1073-4 |
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The use of hybrid hybridomas to target human cytotoxic T lymphocytes A. Lanzavecchia, D. Scheidegger in Eur J Immunol (1987) vol. 17 pp105-11 |
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Advances in understanding of mechanisms of IgE disregulation in atopy by the application of in vitro methods M. Ricci, G. F. Del Prete, E. Maggi, A. Lanzavecchia, S. Romagnani in J Allergy Clin Immunol (1986) vol. 78 pp988-94 |
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Is the T-cell receptor involved in T-cell killing? A. Lanzavecchia in Nature (1986) vol. 319 pp778-80 |
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Antigen presentation by B lymphocytes: a critical step in T-B collaboration A. Lanzavecchia in Curr Top Microbiol Immunol (1986) vol. 130 pp65-78 |
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Antigen-specific interaction between T and B cells A. Lanzavecchia in Nature (1985) vol. 314 pp537-9 |